decitabine or 5-aza-2'-deoxycytidine

Monitor

• liver function tests at baseline

Mechanism of action

• pyrimidine analog incorporated into DNA, traps DNA methyltransferases, inhibitor of DNA hypermethylation in cancer

Notes

in clinical trials for

• myelodysplastic syndrome
• CML
• acute myeloid leukemia
• other solid tumors (lung, ovary, prostate)

More general terms

• pyrimidine antimetabolite; antimetabolite; pyrimidine analog
• antineoplastic agent (chemotherapeutic agent)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=16886
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=451668
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=465300