immune globulin (Gamastan, Gamimune N, Gammagard, Gammar, Sandoglobulin, Venoglobulin-I, Venoglobulin-S, ISG, Vivaglobulin, Gamunex, Privigen, Gammaplex, Flebogamma, Gammaked, Bivigam, Carimune, Hizentra)

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Indications

Contraindications

Caution:

  • do NOT perform skin test: local reaction may occur & be misinterpreted
  • screen for IgA deficiency in hypogammaglobulinemic patients

pregnancy-category C

safety in lactation ?

Dosage

Injection: IM 165 +/- 15 mg (protein)/mL (10 mL) IV: 2.5 g, 3 g, 5 g, 6 g, 10 g.

Pharmacokinetics

  • appears in plasma immediately following IV administration
  • elimination: liver
  • 1/2life is 21-29 days
  • duration of action: 3-4 weeks

Adverse effects

Drug interactions

Mechanism of action

More general terms

More specific terms

Additional terms

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 613-614
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 FDA Safety Communication: June 10, 2013 New boxed warning for thrombosis related to human immune globulin products. http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/ucm355986.htm
  5. 5.0 5.1 5.2 5.3 Deprecated Reference
  6. Patwa HS, Chaudhry V, Katzberg H, Rae-Grant AD, So YT Evidence-based guideline: intravenous immunoglobulin in the treatment of neuromuscular disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2012 Mar 27;78(13):1009-15 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22454268
  7. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015