disease interaction(s) of obesity with psoriasis
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Introduction
Interactions:
- overweight & obesity affect 60%-78% of patients with psoriasis[1]
- affects disease severity, treatment response, & clinical outcomes
Management
- adding tirzepatide (Zepbound) to ixekizumab (Taltz) improves outcomes in adults with difficult-to-treat plaque psoriasis due to overweight or obesity[1]
More general terms
References
- ↑ 1.0 1.1 1.2 Harris S Psoriatic Disease Shown to Increase Risk of Heart Failure. Risk of HF events goes up independently of traditional risk factors. MedPage Today April 29, 2022 https://www.medpagetoday.com/reading-room/acrr/psoriaticarthritis/98455
Harris S Lihi Eder, MD, PhD, on Psoriatic Disease Activity and Cardiovascular Risk. Higher levels of tender and swollen joint counts, inflammatory markers, physical dysfunction linked with non-ischemic heart failure. MedPage Today July 16, 2021 https://www.medpagetoday.com/reading-room/acrr/psoriaticarthritis/93593
Koppikar S, Colaco K, Harvey P et al Incidence of and Risk Factors for Heart Failure in Patients with Psoriatic Disease - A Cohort Study. Arthritis Care & Research. 2021. Feb 11 PMID: https://pubmed.ncbi.nlm.nih.gov/33571391 https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.24578